Early Clinical Intervention and Prevention in Schizophrenia

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Early intervention and recovery for young people with early psychosis: consensus statement. Br J Psychiatry Suppl ; ss International clinical practice guidelines for early psychosis. Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the treatment of schizophrenia and related disorders. Aust N Z J Psychiatry ; The prodromal phase of first-episode psychosis: past and current conceptualizations. Schizophr Bull ; Early intervention in psychosis. The critical period hypothesis.

Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Arch Gen Psychiatry ; Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. Am J Psychiatry ; Early detection of schizophrenia. Curr Opin Psychiatry ; Pathways to care for first-episode psychosis in an early detection healthcare sector: part of the Scandinavian TIPS study.

Reducing the duration of untreated first-episode psychosis: effects on clinical presentation.

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Early detection of the first episode of schizophrenia and suicidal behavior. Early detection of first-episode psychosis: the effect on 1-year outcome. Integrated treatment ameliorates negative symptoms in first episode psychosis — results from the Danish OPUS trial. Schizophr Res ; Improving 1-year outcome in first-episode psychosis: OPUS trial. Integrated treatment of first-episode psychosis: effect of treatment on family burden: OPUS trial.

BMJ ; Specialised care for early psychosis: symptoms, social functioning and patient satisfaction: randomised controlled trial. Br J Psychiatry ; McGorry PD. Evidence based reform of mental health care. Acta Psychiatr Scand ; Is phase-specific, community-oriented treatment of early psychosis an economically viable method of improving outcome?

Birchwood M, Fiorillo A. The critical period for early intervention. Psychiatr Rehabil Skills ; 4: Can J Psychiatry ; Social outcome in early psychosis. Psychol Med ; Early warning signs of relapse following a first episode of psychosis. Early intervention and a five year follow up in young adults with a short duration of untreated psychosis: ethical implications. Gleeson J. Australas Psychiatry ; Want to Read saving…. Want to Read Currently Reading Read.

Other editions. Enlarge cover. Error rating book. Refresh and try again. Open Preview See a Problem? Details if other :. Thanks for telling us about the problem. Return to Book Page. Stone Editor ,. Stephen V. Faraone Editor. Leading and internationally recognized researchers review what is known about the liability to schizophrenia, how it progresses, what it looks like clinically-with an emphasis on a specific proposed syndrome of liability schizotaxia -and how best it might be treated now and in the near future.

Randomized-controlled trials in people at ultra high risk of psychosis: a review of treatment effectiveness. Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first-episode psychosis: do the cognitive deficits progress over, or after, the onset of psychosis? Lim, J. Lin, A.


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Neurocognitive predictors of functional outcome two to 13 years after identification as ultra-high risk for psychosis. Niendam, T. The course of neurocognition and social functioning in individuals at ultra high risk for psychosis. Arango, C. Differential neurodevelopmental trajectories in patients with early-onset bipolar and schizophrenia disorders. Agnew-Blais, J. Early childhood IQ trajectories in individuals later developing schizophrenia and affective psychoses in the new england family studies.

School performance as a premorbid marker for schizophrenia: a twin study. Ullman, V. Real-world premorbid functioning in schizophrenia and affective disorders during the early teenage years: a population-based study of school grades and teacher ratings. Woodberry, K. Premorbid IQ in schizophrenia: a meta-analytic review. Psychiatry , — Meier, M. Neuropsychological decline in schizophrenia from the premorbid to the postonset period: evidence from a population-representative longitudinal study.

Psychiatry , 91— Vorstman, J. Cognitive decline preceding the onset of psychosis in patients with 22q JAMA Psychiatry 72 , — Liu, C. Perinatal risks and childhood premorbid indicators of later psychosis: next steps for early psychosocial interventions. Seidman, L. New targets for prevention of schizophrenia: is it time for interventions in the premorbid phase? Howes, O. The dopamine hypothesis of schizophrenia: version III--the final common pathway. The neurobiology and treatment of first-episode schizophrenia. Psychiatry 20 , 84—97 Schmidt, M.

Neurodevelopment, GABA system dysfunction, and schizophrenia.

Early Intervention for psychosis

Neuropsychopharmacology 40 , — Pocklington, A. Novel findings from CNVs implicate inhibitory and excitatory signaling complexes in schizophrenia. Neuron 86 , — Liu, Z. Sequential interplay of nicotinic and GABAergic signaling guides neuronal development. Science , — Tsai, G. Strategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis.

EPPIC (Early Psychosis Prevention & Intervention Centre) | Orygen Youth Health

D-cycloserine increases positive symptoms in chronic schizophrenic patients when administered in addition to antipsychotics: a double-blind, parallel, placebo-controlled study. Neuropsychopharmacology 21 , — Goff, D. A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia.

Arch Gen Psychiatry 56 , 21—27 Weiser, M. A multicenter, add-on randomized controlled trial of low-dose d-serine for negative and cognitive symptoms of schizophrenia. Psychiatry 73 , e—e Kantrowitz, J. High dose D-serine in the treatment of schizophrenia. Iwata, Y. Effects of glutamate positive modulators on cognitive deficits in schizophrenia: a systematic review and meta-analysis of double-blind randomized controlled trials.

Psychiatry 20 , — Nomura, J. Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice. Psychiatry 21 , — Marx, C. Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia. Psychopharmacology Berl , — Vinkers, C. The inhibitory GABA system as a therapeutic target for cognitive symptoms in schizophrenia: investigational agents in the pipeline.

Drugs 19 , — Rudolph, U. Gill, K.


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A randomized clinical trial of MK for the treatment of cognitive impairments in people with schizophrenia. Psychiatry 69 , — Oberman, L. Modulation of corticospinal excitability by transcranial magnetic stimulation in children and adolescents with autism spectrum disorder. Wang, D. Blocking early GABA depolarization with bumetanide results in permanent alterations in cortical circuits and sensorimotor gating deficits. Cereb Cortex 21 , — Bruining, H. Paradoxical benzodiazepine response: a rationale for bumetanide in neurodevelopmental disorders? Pediatrics , e—e Meck, W.

Choline supplementation during prenatal development reduces proactive interference in spatial memory. Brain Res. Ross, R.


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Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Steullet, P. Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A "central hub" in schizophrenia pathophysiology? Miller, B. C-reactive protein levels in schizophrenia: a review and meta-analysis. Psychoses 7 , — Fineberg, A. Inflammatory cytokines and neurological and neurocognitive alterations in the course of schizophrenia. Psychiatry 73 , — Coughlin, J. Marked reduction of soluble superoxide dismutase-1 SOD1 in cerebrospinal fluid of patients with recent-onset schizophrenia.

Psychiatry 18 , 10—11 Bergink, V. Autoimmunity, inflammation, and psychosis: a search for peripheral markers. Psychiatry 75 , — Monin, A. Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients. Berk, M. The promise of N-acetylcysteine in neuropsychiatry. Trends Pharmacol. Powell, S. Behavioral and neurochemical consequences of cortical oxidative stress on parvalbumin-interneuron maturation in rodent models of schizophrenia. Neuropharmacology 62 , — Jiang, Z. Social isolation exacerbates schizophrenia-like phenotypes via oxidative stress in cortical interneurons.

Cabungcal, J. Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia.

Neuron 83 , — Hashimoto, K. Targeting of NMDA receptors in new treatments for schizophrenia. Targets 18 , — Giordano, E. Long-chain omega 3 fatty acids: molecular bases of potential antioxidant actions. Prostaglandins Leukot. Fatty Acids 90 , 1—4 Lorente-Cebrian, S. An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases. Amminger, G.